I don't know what all is going in to the way she looks (possibly dehydration, supplements, over exercising, starvation...) but the way Madonna looks has more to do with her extremely low levels of body fat, over training and a very restrictive diet losing too much fat and getting what some would call "ripped." This ripped look is what many Figure Competitors look to achieve which takes an extremely regimented, strict eating plan to the point of deprivation along with hours and hours of working out. This look has nothing to do with the amount of muscle she has... but everything to do with the lack of body fat and taking a good thing like a healthy diet and exercise way too far. When you see veins in her arms like that, it means she basically has no body fat. My goal for women is to achieve a look that is strong and healthy and above all that they feel good about themselves, and have energy. Performing exercise 2-4 hours a week and enjoying a splurge guilt free. It is not about losing every last ounce of body fat, being deprived and looking emaciated. Madonna is doing 2 hours a day of exercise (most of which consists of cardio and 2-3 pound dumbbells- OPPOSITE of my philosophies). Doing 2 hours of working out a day, you cannot work at the intensity I recommend you work. Less is more when it comes to exercise. And let's face it she definitely has some genetics playing in to the way she looks.
Just wanted to give you my 2 cents in case you had seen some of these pictures and been a little frightened to touch another dumbbell. Instead, know that you absolutely should lift weights, boost your metabolism and get the benefits of strength training but the most you should work out is 4-6 hours a week (not 12 hours like Madonna does) and you should EAT! Do not starve yourself. Having some body fat is a good thing and keeps you looking feminine. It is about finding a balance to look amazing, feel great and live life to the fullest!
Just wanted to reassure you that the way Madonna looks has nothing to do with lifting too much weight in the gym. Get to the gym, lift weights, push yourself for 45 minutes to an 1 hour max, getting your metabolism cranking so you can eat more, enjoy an occasional splurge and look feminine and feel sexy!